LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010]
Function:
Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the lin-54 family.
Contains 2 CXC domains.
SWISS:
Q6MZP7
Gene ID:
132660
Database links:
Entrez Gene: 132660 Human
Entrez Gene: 231506 Mouse
Entrez Gene: 305171 Rat
SwissProt: Q6MZP7 Human
SwissProt: Q571G4 Mouse
SwissProt: Q641Z1 Rat
Unigene: 96952 Human
Unigene: 212568 Mouse
Unigene: 24111 Rat
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