Lingo-3 is a 592 amino acid single-pass type I membrane protein. Lingo-3 contains one immunoglobulin-like C2-type domain and fourteen leucine-rich repeats and is glycosylated at various positions during post-translational modification. Lingo-3 is expressed in a broad but specific pattern in many tissues across the embryo. The gene encoding Lingo-3 maps to to human chromosome 19p13.3 and mouse chromosome 10 C1. Chromosome 19 consists of approximately 63 million bases and makes up over 2% of human genomic DNA. Chromosome 19 is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc alpha receptors.
Subcellular Location:
Membrane.
Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 11 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
SWISS:
P0C6S8
Gene ID:
645191
Database links:
Entrez Gene: 645191 Human
Entrez Gene: 237403 Mouse
Entrez Gene: 690755 Rat
Omim: 609792 Human
SwissProt: P0C6S8 Human
SwissProt: Q6GQU6 Mouse
Unigene: 371587 Human
Unigene: 40213 Mouse
Unigene: 211966 Rat
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