The Drosophila segment polarity gene lin encodes a protein, lines, which plays important roles in development of the epidermis and hindgut. This gene encodes a protein containing a lines-like domain. This gene is located on chromosome 15 and clustered with the gene encoding ankyrin repeat and SOCS box-containing protein 7. [provided by RefSeq, Sep 2010]
Function:
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
Subcellular Location:
Cytoplasm. Cell surface. Colocalizes with PTPRF at the cell surface.
Tissue Specificity:
Expressed only in brain.
Similarity:
Belongs to the liprin family. Liprin-alpha subfamily.
Contains 3 SAM (sterile alpha motif) domains.
SWISS:
O75145
Gene ID:
8541
Database links:
Entrez Gene: 8541 Human
Entrez Gene: 76787 Mouse
Entrez Gene: 140591 Rat
Omim: 603144 Human
SwissProt: O75145 Human
SwissProt: P60469 Mouse
SwissProt: Q91Z79 Rat
Unigene: 413748 Human
Unigene: 277235 Mouse
Unigene: 105437 Rat
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