This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Subcellular Location:
Secreted.
Similarity:
Belongs to the AB hydrolase superfamily. Lipase family.
SWISS:
P07098
Gene ID:
8513
Database links:
Entrez Gene: 8513 Human
Entrez Gene: 67717 Mouse
Omim: 60396 Human
SwissProt: P07098 Human
SwissProt: Q9CPP7 Mouse
Unigene: 523130 Human
Unigene: 329816 Mouse
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