Rabbit Anti-LSR/Lipolysis Stimulated Lipoprotein Receptor antibody

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ILDR3; Immunoglobulin like domain containing receptor 3; Lipolysis stimulated remnant; Lipolysis-stimulated lipoprotein receptor; LISCH; LISCH protein; LISCH7; Liver specific bHLH Zip transcription factor; LSR; LSR_HUMAN; MGC10659; MGC48312; M

Cat:

SL18296R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human LSR/Lipolysis Stimulated Lipoprotein Receptor:121-220/649<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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LSR is a 649 amino acid single-pass membrane protein that contains one immunoglobulin-like domain and localizes to the cell membrane. Existing as a homotrimer or a homotetramer, LSR is thought to play a role in the clearing of triglyceride-rich lipoproteins from blood, specifically via binding to low density lipoproteins (LDLs) and very low density lipoproteins (VLDLs) and facilitating their uptake into cells. Overexpression of LSR may be associated with increased colon tumor growth, suggesting an involvement for LSR in tumor formation and metastasis. Multiple isoforms of LSR exist due to alternative splicing events. The gene encoding LSR maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes.

Function:
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells.

Subcellular Location:
Cell membrane.

Similarity:
Belongs to the immunoglobulin superfamily. LISCH7 family.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.

SWISS:
Q86X29

Gene ID:
51599

Database links:

Entrez Gene: 51599 Human

SwissProt: Q86X29 Human

Unigene: 466507 Human

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