Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP.
Subcellular Location:
Cytoplasmic.
Tissue Specificity:
Expressed in kidney, brain, liver and lung.
Similarity:
Contains 4 FF domains.
Contains 1 Rho-GAP domain.
SWISS:
Q13017
Gene ID:
394
Database links:
Entrez Gene: 394 Human
Entrez Gene: 11855 Mouse
Entrez Gene: 299012 Rat
Omim: 60536 Human
SwissProt: Q13017 Human
SwissProt: P97393 Mouse
Unigene: 592313 Human
Unigene: 20898 Rat
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