Rabbit Anti-LMBRD2 antibody

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LMBD2_HUMAN; LMBR1 domain-containing protein 2; LMBRD2.

Cat:

SL18310R

Species Reactivity：

(predicted: Human,Mouse,Rat,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human LMBRD2:551-650/695<Cytoplasmic>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Vitamin B12 (cobalamin) is essential in animals and humans for metabolism of methylmalonic acid, for the remethylation of homocysteine to methionine and, consequently, for all S-adenosylmethionine-dependent methylation reactions, including DNA synthesis. The lysosomal cobalamin transporter is required for the export cobalamin from lysosomes allowing its conversion to cofactors. Defects in LMBRD1 are the cause of methylmalonic aciduria and homocystinuria type cblF (MMAFHC), also known as homocystinuria-megaloblastic anemia complementation type F. MMAFHC is a disorder of cobalamin metabolism characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl) due to accumulation of cobalamin in lysosomes. Clinical features of MMAFHC include developmental delay, stomatitis, glossitis, seizures and methylmalonic aciduria in response to vitamin B12. LMBRD2 (LMBR1 domain containing 2) is a 695 amino acid multi-membrane protein that may have similar functions as LMBR1.

Subcellular Location:
Membrane.

Similarity:
Belongs to the LIMR family.

SWISS:
Q68DH5

Gene ID:
92255

Database links:

Entrez Gene: 92255 Human

SwissProt: Q68DH5 Human

Unigene: 294103 Human

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