The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks. The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expression of leiomodin 1 may be linked to Graves' disease and thyroid-associated ophthalmopathy. [provided by RefSeq, Jul 2008]
Subcellular Location:
Cytoplasm. Cytoplasm; cytoskeleton.
Tissue Specificity:
Smooth muscle (heart, skeletal muscle, colon and small intestine), a subset of striated muscle fibers, and at low level in thyroid.
Similarity:
Belongs to the tropomodulin family.
Contains 1 WH2 domain.
SWISS:
P29536
Gene ID:
25802
Database links:
Entrez Gene: 25802 Human
Entrez Gene: 428540 Chicken
Entrez Gene: 56490 Cow
Entrez Gene: 100052019 Horse
Entrez Gene: 93689 Mouse
Entrez Gene: 304816 Rat
Omim: 602715 Human
SwissProt: P29536 Human
SwissProt: Q8BVA4 Mouse
Unigene: 519075 Human
Unigene: 36124 Mouse
Unigene: 66554 Rat
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