The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. LONRF2 is a 754 amino acid protein containing one LON domain, one RING-type zinc finger and six TPR repeats. Two isoforms of LONRF2 are produced by alternative splicing events. The gene encoding LONRF2 maps to human chromosome 2q11.2 and mouse chromosome 1 B.
Function:
LONRF2 contains one Lon domain, one RING type zinc finger and six TPR repeats. The function of LONRF2 is unknown. There are two named isoforms.
Similarity:
Contains 1 Lon domain.
Contains 1 RING-type zinc finger.
Contains 6 TPR repeats.
SWISS:
Q1L5Z9
Gene ID:
164832
Database links:
Entrez Gene: 481336 Dog
Entrez Gene: 164832 Human
Entrez Gene: 381338 Mouse
Entrez Gene: 301361 Rat
SwissProt: Q1L5Z9 Human
SwissProt: B2RT44 Mouse
Unigene: 2276 Human
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