Acyl-CoA:lysophosphatidylglycerol (LPG) acyltransferase catalyzes the reacylation of LPG to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin (Yang et al., 2004 [PubMed 15485873]).[supplied by OMIM, Mar 2008]
Function:
Lysophoshatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor.
Subcellular Location:
Endoplasmic reticulum membrane.
Tissue Specificity:
Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon.
Similarity:
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
SWISS:
Q92604
Gene ID:
9926
Database links:
Entrez Gene: 541208 Cow
Entrez Gene: 609933 Dog
Entrez Gene: 9926 Human
Entrez Gene: 226856 Mouse
Entrez Gene: 679692 Rat
Omim: 610473 Human
SwissProt: Q92604 Human
SwissProt: Q91YX5 Mouse
Unigene: 725196 Human
Unigene: 277958 Mouse
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