This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined. [provided by RefSeq, Jul 2008]
Function:
Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis.
Subunit:
Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85)
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others.
Post-translational modifications:
Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
Similarity:
Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 olfactomedin-like domain.
Contains 1 SUEL-type lectin domain.
SWISS:
O95490
Gene ID:
23266
Database links:
Entrez Gene: 281278 Cow
Entrez Gene: 100052932 Horse
Entrez Gene: 23266 Human
Entrez Gene: 100405265 Marmoset (common)
Entrez Gene: 99633 Mouse
Entrez Gene: 100013683 Opossum
Entrez Gene: 100524685 Pig
Entrez Gene: 100343149 Rabbit
Entrez Gene: 171447 Rat
Entrez Gene: 100551470 Turkey
Omim: 607018 Human
SwissProt: O97817 Cow
SwissProt: O95490 Human
SwissProt: Q8JZZ7 Mouse
SwissProt: O88923 Rat
Unigene: 24212 Human
Unigene: 9776 Mouse
Unigene: 12089 Rat
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