LRP2BP is a 347 amino acid protein that contains one TPR repeat and six Sel1-like repeats. Localized to the plasma membrane and throughout the cytoplasm, LRP2BP interacts with megalin (also known as LRP2) and, via this interaction, is thought to regulate megalin function. Specifically, LRP2BP acts as a scaffold protein that, through its TPR motifs, assists in the sequestration and/or the release of transcription factors that influence megalin’s affects on endocytosis and hormone release. LRP2BP is expressed in colon, testis, small intestine and blood leukocytes, as well as in pancreatic adenocarcinoma cells, suggesting a possible role for LRP2BP in carcinogenesis. Two isoforms of LRP2BP exist due to alternative splicing events.
Function:
May act as an adapter that regulates LRP2 function.
Subcellular Location:
Cytoplasm. Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm.
Similarity:
Contains 6 Sel1-like repeats.
Contains 1 TPR repeat.
SWISS:
Q9P2M1
Gene ID:
55805
Database links:
Entrez Gene: 55805 Human
Entrez Gene: 67620 Mouse
Entrez Gene: 290753 Rat
Entrez Gene: 100073340 Zebrafish
SwissProt: Q9P2M1 Human
SwissProt: Q9D4C6 Mouse
SwissProt: Q569C2 Rat
SwissProt: A5PLI4 Zebrafish
Unigene: 558513 Human
Unigene: 383914 Mouse
Unigene: 108662 Rat
Unigene: 94415 Zebrafish
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