Low-density lipoprotein receptor-related protein 3 (LRP3) is a 770 amino acid protein that contains two CUB domains and four LDL-receptor class A domains. LRP3 is widely expressed with highest expression in skeletal muscle and ovary and lowest expression in testis, colon and leukocytes. LRP3 is potentially a membrane receptor involved in the internalization of lipophilic molecules and/or signal transduction.
Function:
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.
Subcellular Location:
Membrane. Membrane > coated pit.Target information above from: UniProt accession O75074 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .
Tissue Specificity:
Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.
Similarity:
Belongs to the LDLR family.
Contains 2 CUB domains.
Contains 4 LDL-receptor class A domains.
SWISS:
O75074
Gene ID:
4037
Database links:
Entrez Gene: 4037 Human
Entrez Gene: 435965 Mouse
Entrez Gene: 89787 Rat
Omim: 603159 Human
SwissProt: O75074 Human
SwissProt: O88204 Rat
Unigene: 515340 Human
Unigene: 273631 Mouse
Unigene: 145216 Rat
Unigene: 87059 Rat
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