Rabbit Anti-LRP5 + LRP6 antibody

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BMND 1; BMND1; EVR 1; EVR 4; EVR1; EVR4; FLJ90062; FLJ90421; HBM; LDL Receptor Related Protein 5 + 6; Low density lipoprotein receptor related protein 5; Low density lipoprotein receptor related protein 5 precursor; Low density lipoprotein rec

Cat:

SL18366R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human LRP5 + LRP6:521-620/1615

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.

Subcellular Location:
Membrane; single-pass type I membrane protein

Similarity:
Belongs to the LDLR family.
Contains 4 EGF-like domains.
Contains 3 LDL-receptor class A domains.
Contains 20 LDL-receptor class B repeats.

SWISS:
O75197

Gene ID:
4040
4041

Database links:

Entrez Gene: 4040 Human

Entrez Gene: 4041 Human

Entrez Gene: 16973 Mouse

Entrez Gene: 16974 Mouse

Omim: 603506 Human

Omim: 603507 Human

SwissProt: O75197 Human

SwissProt: O75581 Human

SwissProt: O88572 Mouse

SwissProt: Q91VN0 Mouse

Unigene: 4572 Human

Unigene: 584775 Human

Unigene: 6347 Human

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