LRRC3 is a 257 amino acid protein that contains 3 LRR repeats. The gene encoding LRRC3 maps to chromosome 21, the smallest of the human chromosomes. Chromosome 21 contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. Translocations are found to occur between chromosome 21 and 8, and chromosome 21 and 12, in certain leukemias.
Subcellular Location:
Membrane.
Tissue Specificity:
Widely expressed; detected in testis, lung, small intestine, breast, brain, heart, bone marrow, placenta, colon, fetal brain, liver, fetal liver, thymus, salivary gland, spinal cord, spleen, trachea and adrenal gland.
Similarity:
Belongs to the LRRC3 family.
Contains 4 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.
SWISS:
Q9BY71
Gene ID:
81543
Database links:
Entrez Gene: 81543 Human
Entrez Gene: 237387 Mouse
Entrez Gene: 246773 Rat
SwissProt: Q9BY71 Human
SwissProt: P59034 Mouse
SwissProt: P59035 Rat
Unigene: 326579 Human
Unigene: 133301 Mouse
Unigene: 83630 Rat
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