Rabbit Anti-LRRC8D antibody

Home > Product > Antibody > Rabbit Anti-LRRC8D antibody

FLJ10470; FLJ20403; LRC8D_HUMAN; Leucine rich repeat containing 5; Leucine rich repeat containing 8 family member D; Leucine rich repeat containing protein 8D; LRRC 5; LRRC 8D; LRRC5.

Cat:

SL18412R

Species Reactivity：

(predicted: Human,Mouse,Rat,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human LRRC8D:44-153/858<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

prev next

Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

LRRC8D contains 12 LRR (leucine-rich) repeats. The function of this protein is unknown.

Function:
Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8D constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). Mediates the import of the antibiotic blasticidin-S into cell (PubMed:24782309).

Subunit:
Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8E), possibly to form a heterohexamer.

Subcellular Location:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Mainly localizes in the endoplasmic reticulum

Similarity:
Belongs to the LRRC8 family.
Contains 13 LRR (leucine-rich) repeats.

SWISS:
Q7L1W4

Gene ID:
55144

Database links:

Entrez Gene: 55144 Human

SwissProt: Q7L1W4 Human

Unigene: 482087 Human

Product Feedback Wall