Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Function:
Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the snRNP Sm proteins family.
SWISS:
Q9Y4Y9
Gene ID:
23658
Database links:
Entrez Gene: 23658 Human
Entrez Gene: 100044729 Mouse
Entrez Gene: 66373 Mouse
Entrez Gene: 306222 Rat
Omim: 607285 Human
SwissProt: Q9Y4Y9 Human
SwissProt: P62322 Mouse
Unigene: 424908 Human
Unigene: 25642 Mouse
Unigene: 8983 Rat
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