This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus.
Function:
Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome.
Subunit:
LSm subunits form a heteromer with a doughnut shape.
Subcellular Location:
Nuclear
Similarity:
Belongs to the snRNP Sm proteins family.
SWISS:
O95777
Gene ID:
51691
Database links:
Entrez Gene: 417765 Chicken
Entrez Gene: 613630 Cow
Entrez Gene: 51691 Human
Entrez Gene: 76522 Mouse
Entrez Gene: 296913 Rat
Omim: 607288 Human
SwissProt: Q3ZCE0 Cow
SwissProt: O95777 Human
SwissProt: Q6ZWM4 Mouse
SwissProt: B2RZB6 Rat
Unigene: 6283 Chicken
Unigene: 7372 Cow
Unigene: 657737 Human
Unigene: 14059 Rat
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