Rabbit Anti-LTC4S antibody | Sunlong Medical

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Leukotriene C(4) synthase; leukotriene C4 synthase; LTC4 synthase.

Cat:

SL18441R

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human LTC4S:51-150/150

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]

Function:
Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

Subunit:
Homotrimer. Interacts with ALOX5AP and ALOX5.

Subcellular Location:
Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein

Tissue Specificity:
Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets.

DISEASE:
LTC4 synthase deficiency is associated with a neurometabolic developmental disorder characterized by muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.

Similarity:
Belongs to the MAPEG family.

SWISS:
Q16873

Gene ID:
4056

Database links:

Entrez Gene: 4056 Human

Entrez Gene: 17001 Mouse

Entrez Gene: 114097 Rat

Omim: 246530 Human

SwissProt: Q16873 Human

SwissProt: Q60860 Mouse

SwissProt: Q925U2 Rat

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