Rabbit Anti-LUZP4/CT28 antibody

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Cancer/testis antigen 28; CT 8; CT-28; CT28; ENSMUSG00000072927; HOM TES 85; HOM TES 85 tumor antigen; Leucine zipper protein 4; LUZP4; LUZP4_HUMAN; OTTHUMP00000023875; RP1-237H22.1; RP23-463M4.2; Tumor antigen HOM-TES-85.

Cat:

SL18447R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human LUZP4/CT28:31-130/313

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a leucine-zipper protein that was first defined as a cancer testis antigens. The encoded protein is an RNA binding protein that interacts with the mRNA export receptor nuclear RNA export factor 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].]

Function:
Export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Binds NXF1, enhances its RNA-binding activity and is required for its localization to the nuclear rim. Associates with the TREX complex via its interaction with the TREX components THOC1, THOC5 and DDX39B/UAP56. Capable of complementing knockdown of ALYREF/THOC4 and partially complementing a double ALYREF/UIF knockdown in vivo. Required for the growth of the melanoma cell line MeWo (PubMed:25662211).

Subunit:
Interacts NXF1, NXF2, THOC1, THOC5, DDX39B/UAP56 and SRRT.

Subcellular Location:
Nucleus. Cytoplasm. Note=In nuclear speckles. Relocalizes to the cytoplasm during cell division.

Tissue Specificity:
Expressed specifically in testis. Also expressed in a wide variety of cancer types, but particularly high levels of expression observed in melanoma cells.

SWISS:
Q9P127

Gene ID:
51213

Database links:

Entrez Gene: 51213 Human

Omim: 300616 Human

SwissProt: Q9P127 Human

Unigene: 242183 Human

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