Colec12 is a member of the SLClectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. Colec12 is a scavenger receptor that displays several functions associated with host defense. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast and mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells.
Function:
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease.
Subunit:
The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar beta amyloid peptide.
Subcellular Location:
Membrane; Single-pass type II membrane protein. Note=Forms clusters on the cell surface.
Tissue Specificity:
Expressed in perivascular macrophages. Expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). Strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. Weakly expressed in brain, colon, thymus and kidney. Expressed in nurse-like cells. Expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
Similarity:
Contains 1 SLCtype lectin domain.
Contains 3 collagen-like domains.
SWISS:
Q5KU26
Gene ID:
81035
Database links:
Entrez Gene: 421061 Chicken
Entrez Gene: 504741 Cow
Entrez Gene: 81035 Human
Entrez Gene: 140792 Mouse
Entrez Gene: 361289 Rat
Omim: 607621 Human
SwissProt: Q2LK54 Chicken
SwissProt: A6QP79 Cow
SwissProt: Q5KU26 Human
SwissProt: Q8K4Q8 Mouse
SwissProt: Q4V885 Rat
Unigene: 33741 Chicken
Unigene: 4492 Cow
Unigene: 464422 Human
Unigene: 218571 Mouse
Unigene: 31273 Rat
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