Rabbit Anti-LY6E/Stem cell antigen 2 antibody

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Ly-6E ; LY6E_HUMAN ; LY6E_MOUSE ; Lymphocyte antigen 6E ; Retinoic acid-induced gene E protein ; RIG-E ; RIGE; SCA2; TSA1; 9804; SCA-2 ; Stem cell antigen 2 ; Thymic shared antigen 1 ; TSA-1 .

Cat:

SL18452R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human LY6E/Stem cell antigen 1:31-100/131

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoSLV2. [provided by RefSeq, Aug 2021]

Function:
GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoSLV2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482).

Tissue Specificity:
Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.

Similarity:
Contains 1 UPAR/Ly6 domain.

SWISS:
Q16553

Gene ID:
4061

Database links:
SwissProt: Q16553 Human

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