This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].
Function:
GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear.
Subcellular Location:
Secreted.
Tissue Specificity:
Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus.
Similarity:
ngs to the bombesin/neuromedin-B/ranatensin family.
SWISS:
P07492
Gene ID:
2922
Database links:
Entrez Gene: 2922 Human
Entrez Gene: 225642 Mouse
Entrez Gene: 171101 Rat
Omim: 137260 Human
SwissProt: P07492 Human
SwissProt: Q8R1I2 Mouse
SwissProt: P63153 Pig
SwissProt: P24393 Rat
Unigene: 153444 Human
Unigene: 20298 Mouse
Unigene: 10930 Rat
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