This gene encodes a tumor suppressor protein that reduces cell growth by stimulating apoptosis. The first intron of this gene contains the neuronatin gene, which is imprinted and only expressed from the paternal allele. This gene is imprinted in brain where it is differentially expressed from different promoters. Transcription from the upstream promoter occurs preferentially on the maternal allele, and transcripts are preferentially expressed from the downstream promoter on the paternal allele. Alternative promoters and alternative splicing result in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2009]
Function:
May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed in cervical tissues. Down-regulated during bladder cancer progression and in most cervical carcinomas.
Similarity:
Belongs to the BLCAP family.
SWISS:
P62952
Gene ID:
10904
Database links:
Entrez Gene: 10904 Human
Entrez Gene: 53619 Mouse
Entrez Gene: 171113 Rat
Omim: 613110 Human
SwissProt: P62952 Human
SwissProt: P62951 Mouse
SwissProt: P62950 Rat
Unigene: 472651 Human
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