ZDHHC23 is a 409 amino acid multi-pass membrane protein that contains one DHHSLCtype zinc finger and is thought to function as a palmitoyltransferase, catalyzing the transformation of palmitoyl-CoA and a cysteine-conjugated protein to an S-palmitoyl protein and free CoA. ZDHHC23 may play a role in NOS1 regulation and targets the synaptic membrane. By regulating the enzymatic activity of NOS1, ZDHHC23 may effect different pathological conditions including nerve regeneration, neuron loss or survival and pain processing.
Function:
May be involved in NOS1 regulation and targeting to the synaptic membrane.
Subcellular Location:
Membrane.
Similarity:
Belongs to the DHHC palmitoyltransferase family.
Contains 1 DHHSLCtype zinc finger.
SWISS:
Q8IYP9
Gene ID:
254887
Database links:
Entrez Gene: 254887 Human
Entrez Gene: 332175 Mouse
Entrez Gene: 363783 Rat
SwissProt: Q8IYP9 Human
SwissProt: Q5Y5T3 Mouse
SwissProt: Q76IC6 Rat
Unigene: 21902 Human
Unigene: 327852 Mouse
Unigene: 43304 Rat
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