The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 11 C2H2-type zinc fingers.
Contains 1 KRAB domain.
SWISS:
P21506
Gene ID:
7556
Database links:
Entrez Gene: 7556 Human
Omim: 194538 Human
SwissProt: P21506 Human
Unigene: 507355 Human
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