This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function:
Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.
Subcellular Location:
Nuclear
Tissue Specificity:
Widely expressed in various adult tissues and embryonic developmental stages (isoform 3)
DISEASE:
Shows a relatively higher expression level in the fetal brain and a lower level in adult. The expression level in liver is highest at 16 weeks of development and declines from 16 to 24 weeks and is lower in adult. Expressed strongly in fetal heart on 18 and 24 weeks, but relatively weakly on the other development stage of embryo, and then reaches a higher level in adult (isoform 3)
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 15 C2H2-type zinc fingers.
Contains 1 KRAB domain.
SWISS:
P17014
Gene ID:
7559
Database links:
Entrez Gene: 7559 Human
Omim: 194536 Human
SwissProt: P17014 Human
Unigene: 431471 Human
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