The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Function:
Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
SWISS:
Q9NZL9
Gene ID:
27430
Database links:
Entrez Gene: 27430 Human
Entrez Gene: 614177 Cow
Entrez Gene: 479301 Dog
Entrez Gene: 108645 Mouse
Entrez Gene: 100217381 Pig
Entrez Gene: 100358077 Rabbit
Entrez Gene: 683630 Rat
Omim: 605527 Human
SwissProt: Q29RI9 Cow
SwissProt: Q9NZL9 Human
SwissProt: Q99LB6 Mouse
SwissProt: Q5U2R0 Rat
Unigene: 54642 Human
Unigene: 293771 Mouse
Unigene: 1752 Rat
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