This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Function:
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated.
Subcellular Location:
Nucleus. Cytoplasm > cytosol.
Tissue Specificity:
Isoform 1 is strongly expressed in placenta, spleen, kidney, testis and peripheral blood leukocytes. Expressed in CD4+ and CD8+ T-cells, CD19+ B-cells and CB14+ monocytes. Isoform 3 is strongly expressed in placenta, ovary, tonsil, CD19+ B-cells and CD14+ monocytes.
Similarity:
Contains 19 C2H2-type zinc fingers.
SWISS:
Q9P243
Gene ID:
57623
Database links:
Entrez Gene: 522282 Cow
Entrez Gene: 482051 Dog
Entrez Gene: 57623 Human
Entrez Gene: 380993 Mouse
Entrez Gene: 362925 Rat
Omim: 610931 Human
SwissProt: Q9P243 Human
SwissProt: Q7TS63 Mouse
Unigene: 446172 Human
Unigene: 309526 Mouse
Unigene: 33031 Rat
|
|
