Zfp110 (zinc finger protein 110) contains 1 SCAN box domain. The SCAN domain has been shown to be able to mediate homo- and hetero-oligomerisation.
Function:
Transcription regulator involved in NGFR/p75(NTR)-mediated apoptosis. Essential component of the NGFR/p75(NTR) apoptotic pathway: upon ligand-binding and subsequent cleavage of NGFR/p75(NTR), binds to the intracellular domain (ICD) cleavage product of NGFR/p75(NTR), translocates to the nucleus and induces apoptosis, possibly by regulating expression of key regulators of apoptosis. Induces NGFR/p75(NTR)-mediated apoptosis in retina and sympathetic neurons. May also regulate expression of neuronal cholesterol biosynthesis genes. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression.
Subunit:
Interacts with NGFR/p75(NTR). Interacts (via KRAB 1 domain) with TRAF6. Interacts (when ubiquitinated at Lys-15) with SQSTM1/p62.
Tissue Specificity:
Ubiquitously expressed at low level. Expressed at higher level in testis.
Post-translational modifications:
Ubiquitinated by TRAF6 at Lys-15 through 'Lys-63'-linked polyubiquitination. 'Lys-63'-linked polyubiquitination occurs in response to NGFR/p75(NTR) cleavage by gamma-secretase and promotes binding with the ICD cleavage product of NGFR/p75(NTR), followed by tranlocation into the nucleus and subsequent apoptosis.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 5 C2H2-type zinc fingers.
Contains 2 KRAB domains.
Contains 1 SCAN box domain.
SWISS:
Q923B3
Gene ID:
65020
Database links:
Entrez Gene: 65020 Mouse
Entrez Gene: 308362 Rat
SwissProt: Q923B3 Mouse
SwissProt: Q4V8E9 Rat
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