The paraneoplastic antigen MA family contains three known members: MA1, MA2 and MA3. MA1, also designated neuron- and testis-specific protein 1, is a nucleolar protein in normal cells but localizes to the cytoplasm of tumor cells. MA2, also designated onconeuronal antigen MA2, is a nucleolar protein expressed in brain and testis. MA3 is highly expressed in brain and testis and is expressed at low levels in heart, trachea and kidney.
Subcellular Location:
Nucleus > nucleolus.
Tissue Specificity:
Brain specific. In some patients suffering from cancers, it is also specifically expressed by the testicular tumor cells.
Similarity:
Belongs to the PNMA family.
SWISS:
Q9UL42
Gene ID:
603970
Database links:
Entrez Gene: 540301 Cow
Entrez Gene: 10687 Human
Omim: 603970 Human
SwissProt: Q2KIT6 Cow
SwissProt: Q9UL42 Human
Unigene: 591838 Human
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