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Rabbit Anti-TDO2/tryptophan 2,3-dioxygenase antibody
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]
Function:
Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin
Subunit:
Homotetramer (By similarity).
Similarity:
Belongs to the tryptophan 2,3-dioxygenase family.
SWISS:
P48775
Gene ID:
6999
Database links:
Entrez Gene: 6999 Human
Omim: 191070 Human
SwissProt: P48775 Human
Unigene: 183671 Human
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