ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]
Function:
Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.
Subcellular Location:
Nucleus. Cytoplasm. Translocates into the cytoplasm following treatment of the cell with LPS.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the DNA polymerase type-B-like family.
Contains 3 CCHSLCtype zinc fingers.
Contains 2 PAP-associated domains.
SWISS:
Q5TAX3
Gene ID:
23318
Database links:
Entrez Gene: 23318 Human
Entrez Gene: 230594 Mouse
Entrez Gene: 313481 Rat
Omim: 613692 Human
SwissProt: Q5TAX3 Human
SwissProt: B2RX14 Mouse
Unigene: 655407 Human
Unigene: 25181 Mouse
Unigene: 446602 Mouse
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