Predicted to enable laminin binding activity. Predicted to act upstream of or within cell-matrix adhesion. Located in extracellular space. [provided by Alliance of Genome Resources, Nov 2021]
Function:
Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression.
Subunit:
Binds laminin-1 and laminin-5. Interacts with LGALS3 By similarity. Interacts with AGR2 and AGR3.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers.
Post-translational modifications:
N-glycosylated and O-glycosylated.
Similarity:
Contains 2 UPAR/Ly6 domains.
SWISS:
O95274
Gene ID:
27076
Database links:
Entrez Gene: 27076 Human
Omim: 609484 Human
SwissProt: O95274 Human
Unigene: 631594 Human
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