This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
Function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the AB hydrolase 2 family.
SWISS:
O75608
Gene ID:
10434
Database links:
Entrez Gene: 10434 Human
Entrez Gene: 539992 Cow
Entrez Gene: 18777 Mouse
Entrez Gene: 100172358 Orangutan
Entrez Gene: 100125993 Rabbit
Entrez Gene: 25514 Rat
Omim: 605599 Human
SwissProt: Q3MHR0 Cow
SwissProt: O75608 Human
SwissProt: P97823 Mouse
SwissProt: Q5RBR7 Orangutan
SwissProt: O77821 Rabbit
SwissProt: P70470 Rat
Unigene: 435850 Human
Unigene: 299955 Mouse
Unigene: 3594 Rat
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