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Rabbit Anti-Mannosidase II antibody
This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]
Function:
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.
Subunit:
Homodimer; disulfide-linked
Subcellular Location:
Golgi apparatus membrane; Single-pass type II membrane protein
Similarity:
Belongs to the glycosyl hydrolase 38 family.
SWISS:
Q16706
Gene ID:
4124
Database links:
Entrez Gene: 4124 Human
Omim: 154582 Human
SwissProt: Q16706 Human
Unigene: 432822 Human
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