The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Function:
Involved in the specific phosphorylation of microtubule-associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the protein kinase superfamily.
CAMK Ser/Thr protein kinase family. MARK subfamily.
Contains 1 KA1 (kinase-associated) domain.
Contains 1 protein kinase domain.
Contains 1 UBA domain.
SWISS:
P27448
Gene ID:
4140
Database links:
Entrez Gene: 4140 Human
Entrez Gene: 17169 Mouse
Entrez Gene: 170577 Rat
Omim: 602678 Human
SwissProt: P27448 Human
SwissProt: Q03141 Mouse
SwissProt: Q8VHF0 Rat
Unigene: 35828 Human
Unigene: 260504 Mouse
Unigene: 408955 Mouse
Unigene: 420865 Mouse
Unigene: 23232 Rat
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