This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Highly expressed in most normal human tissues, with an exception of in testis, small intestine, colon and peripheral blood leukocyte.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the protein kinase superfamily.
AGC Ser/Thr protein kinase family.
Contains 1 AGSLCkinase SLCterminal domain.
Contains 1 PDZ (DHR) domain.
Contains 1 protein kinase domain.
SWISS:
O15021
Gene ID:
375449
Database links:
Entrez Gene: 461838 Chimpanzee
Entrez Gene: 742730 Chimpanzee
Entrez Gene: 375449 Human
SwissProt: O15021 Human
Unigene: 595458 Human
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