This gene encodes a member of von Willebrand factor A domain-containing protein family. The proteins of this family are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This family member is thought to be play a role in reorganizing and regenerating the corneal matrix in granular and lattice type I dystrophies. It may also be involved in wound healing in the dentin-pulp complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Function:
Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position
Subunit:
Forms a heterodimer with SERPINA5.
Subcellular Location:
Membrane; single-pass type II membrane protein
Tissue Specificity:
Expressed in brain, ovary, testis, salivary gland, trachea and lung.
Post-translational modifications:
N-glycosylated
Similarity:
Belongs to the peptidase S1 family.
Contains 2 CUB domains.
Contains 3 LDL-receptor class A domains.
Contains 1 peptidase S1 domain.
Contains 1 SEA domain.
SWISS:
Q7RTY8
Gene ID:
34965
Database links:
Entrez Gene: 34965 Human
Entrez Gene: 208171 Mouse
SwissProt: Q17RH4 Human
SwissProt: Q7RTY8 Human
SwissProt: Q4PPC3 Mouse
SwissProt: Q8BIK6 Mouse
Unigene: 435490 Human
Unigene: 10968 Rat
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