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Rabbit Anti-MCAK/KIF2C antibody
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Function:
Promotes ATP-dependent removal of tubulin dimers from microtubules. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.
Subunit:
Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.
Subcellular Location:
Cytoplasm; cytoskeleton. Nucleus. Chromosome; centromere. Chromosome; centromere; kinetochore. Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Centromeric localization requires the presence of BUB1 and SGOL2.
Tissue Specificity:
Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation by STK12, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
Similarity:
Belongs to the kinesin-like protein family.
MCAK/KIF2 subfamily.
Contains 1 kinesin-motor domain.
SWISS:
Q99661
Gene ID:
11004
Database links:
Entrez Gene: 11004 Human
Entrez Gene: 73804 Mouse
Entrez Gene: 171529 Rat
Omim: 604538 Human
SwissProt: Q99661 Human
SwissProt: Q922S8 Mouse
SwissProt: Q62909 Rat
Unigene: 144061 Human
Unigene: 247651 Mouse
Unigene: 219966 Rat
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