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Rabbit Anti-MCF2L2 antibody
MCF2L2 is a 1,114 amino acid protein that contains one spectrin repeat, one PH domain, one DH domain and one CRAL-TRIO domain. Expressed at high levels in brain and also present in testis and pancreas, MCF2L2 is thought to function as a GEF, catalyzing the activation of target GTPases. Variations in the gene encoding MCF2L2 may be associated with an increased susceptibility to type 2 diabetes. Multiple isoforms of MCF2L2 exist due to alternative splicing events.
Function:
Probably functions as a guanine nucleotide exchange factor.
Tissue Specificity:
Significantly expressed in brain and modestly in pancreas, brain and testis.
DISEASE:
Genetic variation in MCF2L2 may be associated with susceptibility to noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2.
Similarity:
Belongs to the MCF2 family.
Contains 1 CRAL-TRIO domain.
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 spectrin repeat.
SWISS:
Q86YR7
Gene ID:
23101
Database links:
Entrez Gene: 23101 Human
SwissProt: Q86YR7 Human
Unigene: 208267 Human
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