STAC is a 402 amino acid protein that contains one SH3 (Src homology 3) domain and one cysteine-rich domain (CRD). Expressed in brain, STAC is a neuron-specific protein that localizes to the cytoplasm and, based on the frequent involvement of SH3 and CRD domains in signal transduction, is believed to play a role in neuron-specific signal transduction. In addition, STAC may be involved in protecting cells from apoptosis. Due to its neuron-specific expression and putative role in signal transduction, STAC may be implicated in a variety of hereditary neurological diseases.
Function:
Probably involved in a neuron-specific signal transduction.
Subcellular Location:
Cytoplasmic.
Similarity:
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 SH3 domain.
SWISS:
Q99469
Gene ID:
6769
Database links:
Entrez Gene: 6769 Human
Entrez Gene: 20168 Mouse
Entrez Gene: 363152 Rat
Omim: 602317 Human
SwissProt: Q99469 Human
SwissProt: P97306 Mouse
Unigene: 56045 Human
Unigene: 1414 Mouse
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