The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Function:
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication.
Subcellular Location:
Nucleus. Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.Target information above from: UniProt accession Q7L590 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the MCM10 family.
SWISS:
Q7L590
Gene ID:
55388
Database links:
Entrez Gene: 55388 Human
Entrez Gene: 70024 Mouse
Entrez Gene: MCM10 Rat
Omim: 609357 Human
SwissProt: Q3MIR3 Human
SwissProt: Q5T670 Human
SwissProt: Q7L590 Human
SwissProt: Q9H0D7 Human
SwissProt: Q9H3P9 Human
SwissProt: Q0VBD2 Mouse
SwissProt: Q505F3 Mouse
SwissProt: Q8BMJ1 Mouse
SwissProt: Q8BY66 Mouse
Unigene: 198363 Human
Unigene: 23828 Mouse
Unigene: 447935 Mouse
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