The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]
Function:
Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.
Subunit:
Component of the MCM8-MCM9 complex, which forms a hexamer composed of MCM8 and MCM9.
Subcellular Location:
Nucleus
Similarity:
Belongs to the MCM family.
Contains 1 MCM domain.
SWISS:
Q9NXL9
Gene ID:
254394
Database links:
Entrez Gene: 254394 Human
Entrez Gene: 361852 Rat
Omim: 610098 Human
SwissProt: Q9NXL9 Human
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