Rabbit Anti-MCRS1/p78 antibody

Home > Product > Antibody > Rabbit Anti-MCRS1/p78 antibody

58 kDa microspherule protein; Cell cycle regulated factor (78 kDa); Cell cycle regulated factor p78; Cell cycle-regulated factor p78; ICP22BP; INO80 complex subunit J; MCRS 1; MCRS 2; MCRS1; MCRS1_HUMAN; MCRS2; Microspherule protein 1; MSP 58;

Cat:

SL18734R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human MCRS1/p78:341-440/462

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

prev next

Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

MSP58 is a 462 amino acid protein that localizes to the nucleus and contains one FHA domain. Expressed at high levels during the S phase of the cell cycle and present in testis, prostate, thymus, spleen and colon, MSP58 functions to modulate the transcriptional activity of Daxx (a transcriptional repressor) by recruiting Daxx to the nucleolus. Additionally, MSP58 may play a role in the inhibition of TERT telomerase activity, further implicating MSP58 as an important protein in transcriptional regulation. The gene encoding MSP58 maps to human chromosome 12 and is expressed as multiple alternatively spliced isoforms. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome and is associated wirh hypochondrogenesis, achondrogenesis and Kniest dysplasia.

Function:
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. May be an inhibitor of TERT telomerase activity.
Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Subcellular Location:
Nucleus. Nucleus > nucleolus. In microspherules in the nucleolus.

Tissue Specificity:
Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.

Similarity:
Contains 1 FHA domain.

SWISS:
Q96EZ8

Gene ID:
10445

Database links:

Entrez Gene: 10445 Human

Entrez Gene: 51812 Mouse

Entrez Gene: 300222 Rat

Omim: 609504 Human

SwissProt: Q96EZ8 Human

SwissProt: Q99L90 Mouse

Unigene: 25313 Human

Unigene: 383472 Mouse

Product Feedback Wall