MCTP2 is an 878 amino acid multi-pass membrane protein that belongs to the MCTP family. Existing as five alternatively spliced isoforms, MCTP1 binds calcium via its C2 domains in the absence of phospholipids, and is encoded by a gene that maps to human chromosome 15q26.2. Chromosome 15 houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
Function:
MCTP2 contains C2 domains which bind calcium in the absence of phospholipids. There are 5 isoforms produced by alternative splicing.
Subcellular Location:
Cell Membrane; multipass membrane protein
Similarity:
Belongs to the MCTP family.
Contains 3 C2 domains.
SWISS:
Q6DN12
Gene ID:
55784
Database links:
Entrez Gene: 55784 Human
Entrez Gene: 28849 Mouse
Entrez Gene: 308742 Rat
SwissProt: Q6DN12 Human
SwissProt: Q5RJH2 Mouse
Unigene: 592017 Human
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