Rabbit Anti-phospho-MCSF Receptor (Tyr561) antibody

Home > Product > Antibody > Rabbit Anti-phospho-MCSF Receptor (Tyr561) antibody

MCSF Receptor (phospho Y561); p-MCSF Receptor (Y561); C FMS; CD 115; CD115; CD115 antigen; CFMS; Colony stimulating factor 1 receptor; Colony stimulating factor I receptor; CSF 1 R; CSF 1R; CSF-1 receptor; CSF-1-R; CSF1 R; CSF1R; CSF1R_HUMAN;

Cat:

SL18735R

Species Reactivity：

Human,(predicted: Mouse,Rat,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human MCSF Receptor around the phosphorylation site of Tyr561:NS(p-Y)TF

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Product Overview：

Blank control: Raw264.7. Primary Antibody (green line): Rabbit Anti-phospho-MCSF Receptor (Tyr561) antibody (SL18735R) Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-AF647Dilution: 1μg /test. ProtocolThe cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

prev next

Unit:

Price: $256.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.

Function:
Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed in bone marrow and in differentiated blood mononuclear cells.

Similarity:
Belongs to the protein kinase superfamily.
Tyr protein kinase family.
CSF-1/PDGF receptor subfamily.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.

SWISS:
P07333

Gene ID:
1436

Database links:

Entrez Gene: 1436 Human

Entrez Gene: 12978 Mouse

Omim: 164770 Human

SwissProt: P07333 Human

SwissProt: P09581 Mouse

Unigene: 586219 Human

Unigene: 22574 Mouse

Picture

Blank control: Raw264.7.
Primary Antibody (green line): Rabbit Anti-phospho-MCSF Receptor (Tyr561) antibody (SL18735R)
Dilution: 1μg /10^6 cells;
Isotype Control Antibody (orange line): Rabbit IgG .
Secondary Antibody : Goat anti-rabbit IgG-AF647
Dilution: 1μg /test.
Protocol
The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

Product Feedback Wall