MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subunit:
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Mediator complex subunit 10 family.
SWISS:
Q9BTT4
Gene ID:
84246
Database links:
Entrez Gene: 84246 Human
Entrez Gene: 614276 Cow
Entrez Gene: 28077 Mouse
Entrez Gene: 100190825 Orangutan
SwissProt: Q3ZCF2 Cow
SwissProt: Q9BTT4 Human
SwissProt: Q3U0W8 Mouse
SwissProt: Q9CXU0 Mouse
SwissProt: Q5R6P5 Orangutan
Unigene: 58898 Cow
Unigene: 13885 Human
Unigene: 52583 Mouse
Unigene: 19691 Orangutan
|
|
