The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]
Function:
May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subunit:
Belongs to the Mediator complex subunit 12 family.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Mediator complex subunit 12 family.
SWISS:
Q86YW9
Gene ID:
116931
Database links:
Entrez Gene: 116931 Human
Omim: 611318 Human
SwissProt: Q86YW9 Human
Unigene: 58561 Human
Unigene: 730822 Human
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