The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]).[supplied by OMIM, Nov 2010]
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
Similarity:
Belongs to the Mediator complex subunit 30 family.
SWISS:
Q96HR3
Gene ID:
90390
Database links:
Entrez Gene: 90390 Human
Entrez Gene: 69790 Mouse
Entrez Gene: 299905 Rat
Omim: 610237 Human
SwissProt: Q96HR3 Human
SwissProt: Q9CQI9 Mouse
Unigene: 492612 Human
Unigene: 195562 Mouse
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